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How good are protein disorder prediction programs actually?

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Disorder in proteins is vital for biological function, and structural disorder in protein is more pervasive than you might think. Proteins with disordered regions may also be sticky, and clump together inside and between cells, and are directly implicated in a number of neurodegenerative diseases. Thus, being able to identify disordered regions in proteins is highly important.

Source: sciencedaily.com

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