Organoids have now been created from stem cells to secrete the proteins that form dental enamel, the substance that protects teeth from damage and decay. A multi-disciplinary team of scientists led this effort. This is a critical first step to the long-term goal to develop stem cell-based treatments to repair damaged teeth and regenerate those that are lost. Enamel is made during tooth formation by specialized cells called amelobasts. These cells die off after tooth formation is complete. Consequently, the body has no way to repair or regenerate damaged enamel.