The mechanism of plant defense mediated by the non-expressor of pathogenesis-related (NPR) genes in monocots (plants having a single embryonic leaf) is not well-documented. Now, scientists have discovered how the NPR family of genes regulate immune responses in the model monocot Brachypodium distachyon. These findings provide a blueprint for plants’ defense systems and might contribute to more research towards resilient crop species, boosting pesticide-free cereal crop cultivation.