A new study compares the effectiveness of two antisepsis aqueous solutions in reducing the risk of infection in patients requiring surgery for open fractures. The research team found that contrary to current international recommendations, chlorhexidine gluconate was not superior to povidone-iodine in an alcohol or aqueous solution in preventing surgical site infection. The results suggest health care practitioners can select either aqueous-based antisepsis solution when treating open fractures on the basis of solution availability, patient contraindications, or product cost.