As health care professionals, researchers and consumers increasingly use genetic testing, they are uncovering incidental genetic abnormalities, or variants, that are associated with cardiovascular diseases. The statement writing committee cautions that incidentally identified single gene variants may or may not be risk factors for disease, so it is important to interpret them correctly and cautiously. The new scientific statement offers a framework to support health care professionals in appropriately assessing individual genetic variants, communicating findings with patients and families, and, when needed, how to create a strong multidisciplinary team for individualized care.