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Tucked into the hillsides of Italy, Portugal, and Spain, some of the world’s most famous — and most difficult to maintain — vineyards are heralded for their unique flavor profiles and centuries of tradition. But as extreme weather and changing socioeconomic conditions make this so-called ‘heroic viticulture’ even more challenging, scientists worry these grapes and their cultural histories are at risk. Researchers argue that farmers and scientists must work together to protect some of the world’s most celebrated wines.