A new study has revealed an association between favorable survival outcomes for melanoma patients and the presence of higher populations of tissue-resident memory T cells (TRM). Data obtained from this study could be used not only for a TRM-based machine learning model with predictive powers for melanoma prognosis but could also elucidate the role TRM cells can play in the tumor immune microenvironment. This could guide the development of more effective and personalized anti-tumor immunotherapeutic treatment regimens for cancer patients.